![]() Acoustic trauma did not change the metabolite clusters in these regions. Principal component analysis showed that metabolic patterns varied among different brain regions however, brain regions with similar functions had a similar metabolite composition. After deconvolution of mass spectra and identification of the molecules, the metabolomic data were processed using multivariate statistical analysis. Metabolites in 12 different brain regions collected from either sham or acoustic trauma animals were profiled using a gas chromatography mass spectrometry (GC/MS)-based metabolomics platform. In this study, we made the first attempt to analyse brain metabolic changes in rats following acoustic trauma using metabolomics, as a pilot study prior to directly linking metabolic changes to tinnitus. One obvious and significant gap in tinnitus research is a lack of biomarkers that reflect the consequences of this interactive “tinnitus-causing” network. It has been increasingly recognized that tinnitus caused by acoustic trauma is unlikely to be generated by a single pathological source, but rather a complex network of changes involving not only the auditory system but also systems related to memory, emotion and stress. However, the impact of acoustic trauma on system biology is not fully understood. ![]() 6Department of Neurosurgery, Dunedin Medical School, University of Otago, Otago, New ZealandĪcoustic trauma is the most common cause of hearing loss and tinnitus in humans.5Eisdell Moore Centre for Hearing and Balance Research, University of Auckland, Auckland, New Zealand.4Brain Research New Zealand, Dunedin, New Zealand.3Brain Health Research Centre, University of Otago, Dunedin, New Zealand.2Department of Pharmacology and Toxicology, School of Biomedical Sciences, University of Otago, Dunedin, New Zealand.1Key Laboratory of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, Jiangsu, China.Jun He 1, Yejin Zhu 1, Jiye Aa 1, Paul F.
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